Splatt wrote: ↑Tue Mar 23, 2021 7:37 pm
guy153 wrote: ↑Tue Mar 23, 2021 9:47 am
The research to work out how to do this would require making lots of chimeric viruses in a BSL4 lab somewhere... There might be some risks associated with that.
Indeed. It might escape, infect people in the city it resides in and go global or something. It could cause a global pandemic lasting a year or more...
Despite the odd WHO "investigations" its a theory that cant be discounted.
No absolute proof (and may never be) but the balance of probabilities is on the side of a lab leak.
We know Shi and others were doing research involving creating actual viable fully-fledged chimeric coronaviruses (not messing around with pseudovirus platforms) to explore host range in the US in 2015. They published a paper in Nature all about it (which is a very interesting paper quite apart from the controversy):
About this time the US put a moratorium on such research and it's very likely it moved to the Wuhan lab (where Shi was working).
Then people have uncovered things like this:
"We will use S protein sequence data, infectious clone technology, in vitro and in vivo infection experiments
Infectious clone technology and in vivo infection experiments means making real viruses and infecting animals with them (probably transgenic mice, perhaps hamsters or monkeys). Also interesting to look at who the project leader is on that page. I think he's involved with the WHO whitewash sorry investigation.
So very likely they were making viruses a lot like SARS-CoV-2 in the lab right where the outbreak started of a new virus whose spike was remarkably well-adapted to humans right off the hop, in the middle of a city a long way from any actual bat caves.
It's probably the backbone from a hastily-deleted bat virus with a modified spike: perhaps the spike from a different virus, or perhaps they just added the furin cleavage site. Probably small changes as they would have been doing controlled experiments after all.
Lots of people trying to find actual physical evidence, like the suspicious CGGCGG dimer in the FCS. It is a bit supicious, but also could have arisen naturally. Then there's a bunch of other rather speculative stuff along similar lines. The whole point of the research was to simulate what might happen naturally so it's impossible to tell just from looking at the virus itself whether it did.