Except its not. We have vaccines that reduce severe sickness. Our main vaccine has minimal effect on reducing cases so if you want to follow that route, the public health route is never ending restrictions.thinksaboutit wrote: ↑Sun Feb 28, 2021 5:48 pm A. The public health response is focussed on vaccinating as many adults as possible, to reduce cases, admissions and deaths. But also states that reducing the amount of virus circulating, reduced reproduction and the probability of problem mutations arising.
Mutation rate is going to increase the more we partially vaccinate regardless.
Well E484K is evolved multiple times globally independently and has done so at least twice in the UK as well.. If immunity from vaccination is narrower than that from surviving natural infection, this could lead to a vaccine resistant mutation dominating. There are some here with an absolute conviction that this effect will dominate.
6 variants (i think 7 with todays news) circulating here with it already.
The more epitopes you expose the immune system to the more chance there is of it being recognised by the immune system next time round or destroying it.1. What evidence is there that vaccine derived immunity is narrower than disease derived immunity?
The current vaccines expose a small part and only the spike protein so we're only training on one, highly variable part of the virus. Again look at 484K to see how a small mutation can reduce vaccine neutralisation 6 fold which reduces the effectiveness of all of them and in AZ case, to zero.
There are a couple of whole inactivated virus vaccines (Sinovac etc) and these likely will provide far more resistance to mutation and a better immune response. Nottingham and a few others (Valneva maybe?) are also working on broader epitope vaccines.
Never before have we vaccinated against such a small, specific part of a pathogen.
Natural infection you're exposing the whole virus and many many more targets for the immune system which means that memory is going to be far less weakened when a specific part mutates.